PUBLIC NOTIFICATION OF COMPLETION OF A PILOT TRAUMA STUDY IN MILWAUKEE COUNTY (HYPORESUS)
A research study on the safety and feasibility of controlled fluid resuscitation compared to standard fluid resuscitation for patients with low blood pressure due to severe injury has been completed in Milwaukee County. This study was performed because there is evidence that standard fluid resuscitation may not be beneficial.
About the study
This study, named HypoResus, was performed by the Resuscitation Outcomes Consortium (ROC) – a collaboration of 10 U.S. and Canadian sites that perform emergency research. A total of 192 patients were enrolled in this study between March 2012 and April 2013. Milwaukee County was one of the ROC sites where Milwaukee County Emergency Medical Services and the Medical College of Wisconsin performed this research.
Of the 192 patients enrolled throughout ROC, 36 patients were enrolled in Milwaukee County between August 2012 and January 2013. Twenty-eight (78%) were male and 8 (22%) were female. The average age was 40. Eleven (31%) were Caucasian, 17 (47%) were African-American and 8 (22%) were unreported race. Three (8%) were Hispanic.
Study results
This study found that controlled fluid resuscitation is safe and feasible. Study patients treated with controlled fluid resuscitation received on average one liter less of fluid than patients getting standard fluid resuscitation. There was no statistically significant difference in the death rate of patients who received controlled fluid resuscitation (5.2%) compared to those that received standard fluid resuscitation (14.7%). There was also no statistically significant difference in the rate of kidney failure or how many days they needed to be in the intensive care unit or on a ventilator.
Although this study found that controlled fluid resuscitation is safe and feasible, the benefits of this method need to be confirmed by a larger study.
For additional information, please contact Dr. Tom Aufderheide at (414) 805-6493 or via email at RRC@mcw.edu.
